CTGaming: A Problem-Oriented Registry for Clinical TeleGaming Rehabilitation and Intervention
2011 Journal of Emerging Technologies in Web Intelligence 3(1):28-37.
A clinical telegaming registry, called CTGaming, has been added as a new Problem-Oriented Registry
of Tags And Labels (PORTAL) to the collection of prototype PORTAL registries for ongoing development
of the PORTAL-DOORS System (PDS). As a distributed system of interacting PORTAL registries and DOORS
directories, PDS provides metadata management services for who-what-where metadata about both online
and offline resources. For the CTGaming PORTAL, the scope of the problem-oriented specialty domain
for the registry encompasses gaming in physiotherapy, rehabilitation and intervention via telecare,
and in general, diagnostic and therapeutic telegaming. This new PORTAL registry has also been incorporated
into the design of an existing clinical telegaming system (CTGS). Operating as an adaptive gaming application
for telerehabilitation, the CTGS functions either locally in a clinical care setting or remotely in
a telecare setting in patients' homes. Operating in concert with the CTGS, the CTGaming PORTAL has
been established as a host for metadata representations of resources in the field of clinical telegaming
with metadata representations for resources relevant to the CTGS served upon request. These resources
may include external resources from the public web as well as internal resources such as telegaming
session data from the private medical records associated with the CTGS.
A New PDS PORTAL for Clinical TeleGaming Rehabilitation and Intervention 2010 IEEE
BIBM, Hong Kong China.
A registry for resources relevant to Clinical TeleGaming, called CTGaming, has been added as a new
Problem Oriented Registry of Tags And Labels (PORTAL) to the collection of prototype PORTAL registries
for ongoing development of the PORTAL-DOORS System (PDS). As a distributed system of interacting PORTAL
registries and DOORS directories, PDS provides management services for who-what-where metadata about
both online and offline resources. For the CTGaming PORTAL, the scope of the problem-oriented specialty
domain for the registry encompasses gaming in physiotherapy, rehabilitation and intervention via telecare,
and in general, diagnostic and therapeutic telegaming.
Concept Validating Methods for Maintaining the Integrity of Problem Oriented Domains in the PORTAL-DOORS
System 2010 AMIA IDAMAP, Washington DC.
As a distributed system of interacting PORTAL registries and DOORS directories, the PORTAL-DOORS System
(PDS) provides management services for who-what-where metadata about both online and offline resources.
PDS has been designed to facilitate search of varying scope both within and across registries and directories
focused on different problem oriented domains. Maintaining the integrity of these problem oriented
domains remains an essential requirement for maintaining the efficiency of search throughout the system.
This report describes the new methods used in PDS to distinguish different specialty domains and demonstrates
the approach for several registries including GeneScene and ManRay with concepts such as genes and
radiopharmaceuticals. Metadata records are now tested by concept validating methods for the presence
of any concepts required for each problem oriented domain. Invalid records are moved to a more appropriate
registry or else deleted.
The ManRay Project in Biomedical Informatics for Nuclear Medicine and PharmacoGenomic Molecular
Imaging 2010 WRSNM Conference, Garden Grove CA.
The ManRay Ontology for Nuclear Medicine has been updated for OWL 2 and incorporated with the ManRay
Registry in the PORTAL-DOORS System (PDS) for management of resource metadata on the semantic web.
Use of this ontology and registry will facilitate exchange of data for basic research or clinical trials
involving nuclear medicine and pharmacogenomic molecular imaging for personalized medicine.
- A Distributed Infrastructure
for Metadata about Metadata: The HDMM Architectural Style and PORTAL-DOORS System 2010 Future
Use of NLM Medical Subject Headings with the MeSH2010 Thesaurus in the PORTAL-DOORS System
2010 HealthGrid Conference, Paris.
The NLM MeSH Thesaurus has been incorporated for use in the PORTAL-DOORS System (PDS) for resource
metadata management on the semantic web. All 25588 descriptor records from the NLM 2010 MeSH Thesaurus
have been exposed as web accessible resources by the PDS MeSH2010 Thesaurus implemented as a PDS PORTAL
Registry operating as a RESTful web service. Examples of records from the PDS MeSH2010 PORTAL are demonstrated
along with their use by records in other PDS PORTAL Registries that reference the concepts from the
MeSH2010 Thesaurus. Use of this important biomedical terminology will greatly enhance the quality of
metadata content of other PDS records thus improving cross-domain searches between different problem
oriented domains and amongst different clinical specialty fields.
Use of the MeSH Thesaurus in the PORTAL-DOORS System 2010 AMIA Summit Clinical Research
Informatics, San Francisco.
The Hierarchically Distributed Mobile Metadata (HDMM) Style of Architecture for Pervasive Metadata
Networks ISPAN 2009 Intl Symposium on Pervasive Systems, Algorithms and Networks, Kiaosiung,
The Internet Registry Information Service (IRIS) registers domain names while the Domain Name System
(DNS) publishes domain addresses with mapping of names to addresses for the original web. Analogously,
the Problem Oriented Registry of Tags And Labels (PORTAL) registers resource labels and tags while
the Domain Ontology Oriented Resource System (DOORS) publishes resource locations and descriptions
with mapping of labels to locations for the semantic web. Both the IRIS-DNS System and the PORTAL-DOORS
System share a common architectural style for pervasive metadata networks that operate as distributed
metadata management systems with hierarchical authorities for entity registering and attribute publishing.
Hierarchical control of metadata redistribution throughout the registry-directory networks constitutes
an essential characteristic of this architectural style called Hierarchically Distributed Mobile Metadata
(HDMM) with its focus on moving the metadata for who what where as fast as possible from servers in
response to requests from clients.
Knowledge Engineering for PharmacoGenomic Molecular Imaging of the Brain SKG 2009
Intl Conference Semantics Knowledge Grid, Zhuhai, China.
Schizophrenia, Alzheimer's disease, Parkinson's disease, and other neuropsychiatric degenerative disorders
and dementias impose an enormous economic and psychosocial burden on society, communities, and families.
In order to gain a better understanding of gene-brain-behavior relationships, improve treatment, and
find cures for these diseases, translational research must be conducted with clinical trials of new
drugs and other interventions followed by genotyping and imaging biomarkers for patients with these
neuropyschiatric degenerative disorders. This research, involving pharmacogenomic molecular imaging
of the brain, will be extremely costly in many ways. Therefore, knowledge engineering with effective
software tools and applications built upon a semantic-enabled informatics infrastructure remains a
necessary prerequisite to facilitate a reduction of those research costs by maximizing the benefit
obtained from existing data and minimizing the cost of generating new data. A knowledge engineering
framework that serves this goal must operate in a cross-disciplinary manner that integrates data from
diverse biomedical fields while at the same time incorporating the relevant computational mathematics,
statistics, and informatics analyses for productive data mining.
Biomedical Informatics for Brain Imaging and Gene-Brain-Behavior Relationships 2009
W3C HCLS F2F Meeting, Cambridge.
Alternative Bootstrapping Design for the PORTAL-DOORS Cyberinfrastructure with Self-Referencing
and Self-Describing Features 2009 book chapter in Semantic Web , IN-TECH
Application of the PORTAL-DOORS System for Use by Clinical Trials Registries 2009
AMIA Summit Translational Bioinformatics, San Francisco.
Implementation of Prototype Biomedical Registries for PORTAL-DOORS 2009 AMIA Summit
Translational Bioinformatics, San Francisco.
Corrections to "DOORS to the Semantic Web and Grid With a PORTAL for Biomedical Computing"
2008 IEEE TITB 12(3):411.
DOORS to the Semantic Web and Grid With a PORTAL for Biomedical Computing 2008 IEEE
The semantic web remains in the early stages of development. It has not yet achieved the goals envisioned
by its founders as a pervasive web of distributed knowledge and intelligence. Success will be attained
when a dynamic synergism can be created between people and a sufficient number of infrastructure systems
and tools for the semantic web in analogy with those for the original web. The domain name system (DNS),
web browsers, and the benefits of publishing web pages motivated many people to register domain names
and publish web sites on the original web. An analogous resource label system, semantic search applications,
and the benefits of collaborative semantic networks will motivate people to register resource labels
and publish resource descriptions on the semantic web. The Domain Ontology Oriented Resource System
(DOORS) and Problem Oriented Registry of Tags and Labels (PORTAL) are proposed as infrastructure systems
for resource metadata within a paradigm that can serve as a bridge between the original web and the
semantic web. Registers domain names while DNS publishes domain addresses with mapping of names to
addresses for the original web. Analogously, PORTAL registers resource labels and tags while DOORS
publishes resource locations and descriptions with mapping of labels to locations for the semantic
web. BioPORT is proposed as a prototype PORTAL registry specific for the problem domain of biomedical
PORTAL-DOORS Infrastructure System for Translational Biomedical Informatics on the Semantic Web
and Grid 2008 AMIA Summit Translational Bioinformatics, San Francisco.
The ManRay Project: Initial Development of a Web-Enabled Ontology for Nuclear Medicine
2006 Annual Meeting Society Nuclear Medicine, San Diego.